Publications in Peer Reviewed Journals

Mikl, C., Peters, J., Trapp, M., Kornmueller, K., Schneider, WJ., Prassl, R.
Softness of Atherogenic Lipoproteins: A Comparison of Very Low Density Lipoprotein (VLDL) and Low Density Lipoprotein (LDL)Using Elastic Incoherent Neutron Scattering (EINS) (2011)
J. Am. Chem. Soc. 2011, 133, 13213?13215   

Almer, G., Saba-Lepek, M., Haj-Yahya, S., Rohde, E., Hofmeister, A., Strunk, D., Fröhlich, E., Prassl, R., Mangge, H. The globular domain of adiponectin-a promising target molecule for the detection of atherosclerotic lesions. (2011)
Biologics: Targets and Therapy 2011:5 95-105

Almer, G., Wernig, K., Saba-Lepek, M., Haj-Yahya, S., Rattenberger, J., Wagner, J., Gradauer, K., Frascione, D., Pabst, G., Leitinger, G., Mangge, H., Zimmer, A., Prassl, R.
gAdiponectin-coated nanoparticles for enhanced imaging of atherosclerotic plaques (2011) 
International Journal of Nanomedicine 2011:6 1279 ?1290

Helbok, A., Rangger, C., Saba-Lepek, M., Andreae, F., Radolf, T., Thurner, G., Prassl, R., Von Guggenberg, E., Decristoforo, C.
Targeting properties of peptide modified radiolabelled liposomal nanoparticles.
Nanomedicine: Nanotechnology, Biology and Medicine (2011)

Burian, B., Ortner, A., Prassl, R., Zimmer, A. and Mosgoeller, W. Clinical potential of VIP by modified pharmako-kinetics and delivery mechanisms  Endocrine, Metabolic & Immune Disorders - Drug Targets  (2011)

Röhrl, C., Meisslitzer-Ruppitsch, C., Bittman, R., Li, Z., Pabst, G., Prassl, R., Strobl, W., Neumüller, J., Ellinger, A., Pavelka, M., Stangl, H. Combined Light and Electron Microscopy using Diaminobenzidine Photooxidation to Monitor Trafficking of Lipids Derived from Lipoprotein Particles . Special Issue: New methodology and approaches in lipid transport in atherosclerosis and cardiovascular disease.
Current Pharmaceutical Biotechnology (2011)

Prassl, R.,  Human low density lipoprotein (LDL): the mystery of  core lipid packing. (2011)
J. Lipid Res. 2011 52 : 187-188.

Stark, B., Pabst, G., Prassl, R., Long-term stability of sterically stabilized liposomes by freezing and freeze-drying: Effects of cryoprotectants on structure (2010) European Journal of Pharmaceutical Sciences 41 : 546-555.

Helbok, A., C. Decristoforo, G. Dobrozemsky, C. Rangger, E. Diederen, B. Stark, R. Prassl, E. vonGuggenberg.
Radiolabelling of lipid based nanoparticles for diagnostics and therapeutic applications - a comparison using different radiometals (2010)   J.Liposome Research Sep;20(3):219-27

Prassl, R., M. Pregetter, H. Amenitsch, M. Kriechbaum, R. Schwarzenbacher, M.J. Chapman
Low Density Lipoproteins as Circulating Fast Temperature Sensors (2008) PlosOne 3(12):e4079.

Schicher, M. Polsinger, M., Hermetter, A., Prassl, R. and Zimmer.A
In Vitro Release of Propofol and Binding Capacity with regard to Plasma Constituents. (2008)
European Journal of Pharmaceutics and Biopharmaceutics 70(3) : 882-8 

Stark, B., F. Andreae, W. Mosgöller, M. Edetsberger, E. Gaubitzer, G. Köhler, and R. Prassl
Liposomal Vasoactive Intestinal Peptide for Lung Application : Protection from Proteolytic Degradation. European Journal of Pharmaceutics and Biopharmaceutics. 70(1) :153-164 (2008).

Hajos, F., B. Stark, S. Hensler, R. Prassl, and W. Mosgoeller Inhalable liposomal formulation for vasoctive intestinal peptide. Internal Journal of Pharmaceutics 357 : 286-294 (2008).

Stark, B., P. Debbage, F. Andreae F., W. Mosgoeller, and R. Prassl, Association of vasoactive intestinal peptide with polymer-grafted liposomes : Structural aspects for pilmonary delivery. Biochim.Biophys.Acta 1768, 705-714 (2007).

Stark, B., F. Andreae, P. Debbage, W. Mosgoeller, and R. Prassl, Liposomal drug delivery system for pulmonary application of vasoactive intestinal peptide. Proceedings of the Aerosol Society 308-311 (2006).

Johs, A., M. Hammel, I. Waldner, R.P.May, P. Laggner, and R. Prassl, Modular structure of solubilised human apolipoprotein B-100: Low resolution model revealed by Small Angle Neutron Scattering, J.Biol.Chem. 281(28) : 19732-9 (2006).

Gamsjäger, R., A. Johs, A. Gries, H.J.Gruber, C.Romanin, R. Prassl, and P. Hinterdorfer, Membrane binding of ß₂-Glycorprotein I can be described by a two-state reaction model ? an atomic force microscopy and surface plasmon resonance study. Biochemical Journal 389, 3, 665-673 (2005).

Lochmann, D., J. Weyermann, C. Geogens, R. Prassl, and A. Zimmer, Albumin-Protamine-Oligionucleotide Nanoparticles as a new antisense delivery system : Part 1, Physicochemical characterisation. Eur J Pharm Biopharm. Apr;59(3):419-29 (2005).

Hammel, M., M. Walther, R. Prassl and H. Kuehn, Structural Flexibility of the N-terminal beta-Barrel Domain of 15-Lipoxygenase-1 Probed by Small Angle X-ray Scattering. Functional Consequences for Activity Regulation and Membrane Binding. J. Mol. Biol. 29, 343(4), 917-29 (2004).

Hammel, M., P. Laggner, and R. Prassl, Structural characterization of nucleoside loaded low density lipoprotein as a main criterion for the applicability as drug delivery system.Chem. Phys. Lip. 123/2, 193 ? 207 (2003).

Hammel, M., M. Kriechbaum, A. Gries, G. M. Kostner, P. Laggner, and R. Prassl, Solution structure of human and bovine b₂-Glycoprotein I revealed by small angle x-ray scattering. J. Mol. Biol. 321/1, 85-97R. (2002).

Hammel, M., R. Schwarzenbacher, A. Gries, G. M. Kostner, P. Laggner and R. Prassl, Mechanism of the Interaction of b₂-Glycoprotein I with Negatively Charged Phospholipid Membranes.Biochemistry, 40, 14173-14181 (2001).

Schwarzenbacher, R., K. Zeth, K.Diederichs, A. Gries, G.M. Kostner, P. Laggner, and R. Prassl, Crystal structure of human beta2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome.EMBO J., 18, 6228-6239.(1999).

Abuja, P.M., K. Lohner and R. Prassl, Modification of Lipid-Protein Interaction in Human Low Density Lipoprotein Destabilizes ApoB-100 and Decreases Oxidizability. Biochemistry, 38, 3401 - 3408 (1999).

Pregetter, M., R. Prassl, B. Schuster, M.Kriechbaum, F. Nigon, M. J. Chapman and P. Laggner, Microphase Separation in Low Density Lipoproteins Evidence for a fluid triglyceride core below the lipid melting transition. J. Biol. Chem., 274, 3, 1334-1341 (1999).

Saxena, A., A. Gries, R. Schwarzenbacher, G.M. Kostner, P. Laggner and R. Prassl, Crystallization and preliminary X-ray crystallographic studies on apolipoprotein H (ß2-glycoprotein-I) from human plasma. Acta Cryst. D54, 1450-1452 (1998).

Gallová, J., P.M. Abuja, M. Pregetter, P. Laggner and R. Prassl, Site-Specific effect of radical scavengers on the resistance of low density lipoprotein to copper-mediated oxidative stress: influence of a-tocopherol and temperature Chem. Phys. Lipids 92, 139-149 (1998).

Prassl, R., B. Schuster, P. Laggner, C. Flamant, F. Nigon and M.J. Chapman, Thermal Stability of Apolipoprotein B100 in Low Density Lipoprotein is Disrupted at early Stages of Oxidation While Neutral Lipid Core Organization Is Conserved. Biochemistry 37: 938-944 (1998).

Prassl, R., M.J Chapman, F. Nigon, M. Sara, S. Eschenburg, C. Betzel, A. Saxena, and P. Laggner, Crystallization and Preliminary X-ray Analysis of a Low Density Lipoprotein from Human Plasma.J. Biol. Chem. 271, 46, 28731-28733 (1996).

Schuster, B., R. Prassl, F. Nigon, M.J. Chapman, and P. Laggner, Core Lipid Structure is a Major Determinant of the Oxidative Resistance of Low Density Lipoprotein. Proc. Natl. Acad. Sci. USA 92:2509‑2513 (1995).

 

Review Articles  and Book Chapters

Prassl, R.  Apolipoprotein B100 : A highly dynamic structure
In.: Handbook of Lipoprotein Research, Ed. J.E. Rathbond, Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions, Nova Science Publishers Inc. (ISBN:978-1-61668-186-9)  Chapter 12, 207-215. (2011).

Prassl, R. and Laggner P.
Molecular Structure of Low Density Lipoprotein. Current Status and Future Challenge
Eur. Biophys. J. Biophys. Lett  38,2, 145 -158 (2009).

Prassl, R., M. Hammel, and P. Laggner.
Small-Angle Solution Scattering of Proteins.
Recent Advances and Research Updates 7, 1, 305-316 (2006).

Prassl, R., B. Schuster, and P. Laggner, Physico-Chemical Characterization of Low Density Lipoprotein. Subspecies and Modifications in "Supramolecular Structure and Function" (ed. G. Pifat), Balaban Press, Rehovot, 47-74 (1997).

 

 

Published Abstracts

 

Waldner-Scott, I., A. Johs, P.Laggner, and R. Prassl, Low Resolution Model of Solubilized Apolipoprotein B-100. Biophys. J. 94:2776 (2008).

Pazmandi, C., B. Stark, F. Hajos, F. Andreae, A. Artl,  S. Hensler, R. Prassl, and, W. Mosgoeller, Functional liposomes as retard formulation for vasoactive intestinal peptide. Journal of Molecular Neuroscience, 33, 325 (2007).

Saba-Lepek, M., and R. Prassl, Lectin targeted stealth liposomes, FEBS Journal, 274, 365 (2007).

Waldner, I., and R. Prassl, Structural and biophysical characterization of solubilzed apolipoprotein B-100, Eur. Biophys.J. 36(Suppl1) : S51-S248, p.102 (2007).

Johs, A., I. Waldner, P. Laggner, R. Prassl, M. Hammel, and R. P. May, Apolipoprotein B-100: a closer look at the protein moiety of a human blood cholesterol carrier. Scientific Highlight, ILL Annual Report (2006).

Johs, A., M. Hammel, I. Waldner, R.P. May, Laggner, and R. Prassl, Low Resolution Model of Solubilized Apolipoprotein-B100, Atherosclerosis 7/3, 500 (2006).

Johs, A., I. Waldner, M. Hammel, and R. Prassl, Morphology of detergent solubilized apolipoprotein B100, Eur. Biophys.J. 34/6, 737 (2005).

Johs, A., R. Gamsjäger, H.J. Gruber, C. Romanin, P. Hinterdorfer, A. Gries, R. Prassl, Interaction of ß2- glycoprotein I with negatively charged phospolipids. Chem.Phys. Lipids 130 (1), 36 (2004).

Hammel, M., P. Laggner, and R. Prassl, Characterization of nucleoside loaded low density lipoprotein (LDL) as model system for drug delivery, Chem.Phys.Lipids 118 (1-2), 107 (2002).

Johs, A., A. Gries, P. Laggner, and R. Prassl, Structural studies on protein-lipid interactions in cubic lipid phases, Chem.Phys.Lipids 118 (1-2), 51 (2002).

Prassl, R., M.J. Caslake, C.J. Packard, M.K. Palmer, J.M. Chapman, P.N. Durrington, and P. Laggner, Rosuvastatin enhances lipid fluidity in atherogenic apo-B containing lipoproteins. Atherosclerosis 3/2 Suppl. 187 (2002).

Prassl, R., R. Schwarzenbacher, M.Kriechbaum, H. Amenitsch, M. J. Chapman, and P.Laggner, Low Resolution X-ray Crystallography on Human Low Density Lipoprotein. Biophys. J. 78(1), 484 (2000).

Prassl, R., R. Schwarzenbacher, A. Gries, G. M. Kostner, M. J. Chapman, F. Nigon, and P. Laggner,Crystallographic Studies on Human Plasma Lipoproteins.Atherosclerosis, 144(1), 104 (1999).

Pregetter, M., R. Prassl, H. Amenitsch, F. Nigon, M. J. Chapman, and P Laggner, Time-Resolved X-Ray Diffraction of the Core Lipid Transition of Human Low Density Lipoproteins. Atherosclerosis, 144(1), 42 (1999).

Gailhofer, M., R. Prassl, and P. Laggner, Determining Thermal Phase Separation between Triglycerides and Cholesteryl Esters in Human LDL Using Electron Spin Resonance. In "26. Hauptversammlung der Gesellschaft Deutscher Chemiker und 100 Jahrfeier der Gesellschaft Österreichischer Chemiker" (Ed.: Gesellschaft Deutscher Chemiker), Frankfurt/Main, p. 498 (1997).

Saxena, A., R. Prassl, M.J.Chapman, F. Nigon, M. Sara and P. Laggner, Crystallization and Crystallographic Investigations of Low Density Lipoprotein (LDL) from Human Plasma. In "Proceedings of the International Conference on Molecular Structural Biology" (eds. A.J. Kungl, P.J. Andrew & H. Schreiber) GÖCH-Eigenverlag, Vienna, Austria, (1997).

Prassl, R., M. Gailhofer, M.J. Chapman, F. Nigon, B. Schuster and P. Laggner, Evidence for a Lipid Microphase Separation in Human Low Density Lipoprotein, In "Atherosclerosis. XI. Proceedings of the 11th International Symposium on Atherosclerosis?, Elsevier, Paris, Vol(134), p. 226 (1997).

Laggner P., R. Prassl, A. Saxena, F. Nigon, M. Sara, S. Eschenburg, C. Betzel, and JM. Chapman, Crystallization and Preliminary-X-Ray Crystallography of a Low-Density-Lipoprotein from Human Plasma., Biophys. J. 72(2) (1997).